13 research outputs found

    Ring Expansion of Cyclobutylmethylcarbenium Ions to Cyclopentane or Cyclopentene Derivatives and Metal-Promoted Analogous Rearrangements

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    Genome Mining Reveals trans-AT Polyketide Synthase Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes

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    Trans-AT polyketide synthases (PKSs) are a recently discovered group of biosynthetic enzymes present in many bacteria. A strategy for the prediction of natural product structures from trans-AT PKS sequences was demonstrated to be a useful approach for the targeted isolation of bioactive polyketides from chemically poorly studied prokaryotic phyla, as exemplified by the elansolid-type antibiotics

    Defining the high-risk breast cancer patient

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